Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC016
Sex MALE
Dominant hand LEFT
Test date and time 2022-03-23 10:31
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.67 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.67 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 7, 'TN': 7, 'TP': 35, 'FP': 23}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 25, 'TN': 20, 'TP': 17, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 29, 'TN': 25, 'TP': 13, 'FP': 5}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 17, 'TN': 10, 'TP': 25, 'FP': 20}

Test Battery Details

Circle

numCircles 9
timePerCircleMean 20.4222
timePerCircleCoV 0.400161
timePerCircleSlope -0.122252
meanError 1.73169
tremorFreq 6.73828
tremorRelPower 29.8604
tremorGyroAmpMean 0.00985852
tremorGyroAmpSlope 0.00119691
tremorGyroAmpCoV 0.354965
tremorCoordAmpMean 0.0308292
tremorCoordAmpSlope 0.000821852
tremorCoordAmpCoV 0.832486
tremorAccAmpMean 0.0203731
tremorAccAmpSlope 0.00265407
tremorAccAmpCoV 0.371323
tremorPcRelVar 0.525894
tremorPcX 0.473314
tremorPcY -0.880894

Circle Segment 1

Duration 27.12 s, Accuracy Estimate 1.284 (lower is better)

Circle Segment 2

Duration 35.96 s, Accuracy Estimate 1.757 (lower is better)

Circle Segment 3

Duration 28.8 s, Accuracy Estimate 3.398 (lower is better)

Circle Segment 4

Duration 16.84 s, Accuracy Estimate 1.205 (lower is better)

Circle Segment 5

Duration 18.84 s, Accuracy Estimate 1.007 (lower is better)

Circle Segment 6

Duration 14.16 s, Accuracy Estimate 1.584 (lower is better)

Circle Segment 7

Duration 13.48 s, Accuracy Estimate 1.563 (lower is better)

Circle Segment 8

Duration 14.52 s, Accuracy Estimate 1.783 (lower is better)

Circle Segment 9

Duration 14.08 s, Accuracy Estimate 2.004 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 33.672
timePerSpiralCoV 0.135338
timePerSpiralSlope -0.0248242
meanError 1.76775
tremorFreq 5.76172
tremorRelPower 25.0286
tremorGyroAmpMean 0.0140677
tremorGyroAmpSlope -0.000125454
tremorGyroAmpCoV 0.329049
tremorCoordAmpMean 0.0479946
tremorCoordAmpSlope 4.34931e-05
tremorCoordAmpCoV 1.81111
tremorAccAmpMean 0.0897802
tremorAccAmpSlope -7.95295e-06
tremorAccAmpCoV 0.0535859
tremorPcRelVar 0.694383
tremorPcX 0.85175
tremorPcY -0.523948

Spiral Segment 1

Duration 43.52 s, Accuracy Estimate 1.871 (lower is better)

Spiral Segment 2

Duration 34.16 s, Accuracy Estimate 1.732 (lower is better)

Spiral Segment 3

Duration 37.08 s, Accuracy Estimate 1.811 (lower is better)

Spiral Segment 4

Duration 32.32 s, Accuracy Estimate 1.71 (lower is better)

Spiral Segment 5

Duration 30.44 s, Accuracy Estimate 1.809 (lower is better)

Spiral Segment 6

Duration 26.96 s, Accuracy Estimate 1.861 (lower is better)

Spiral Segment 7

Duration 33.68 s, Accuracy Estimate 1.632 (lower is better)

Spiral Segment 8

Duration 35.88 s, Accuracy Estimate 1.71 (lower is better)

Spiral Segment 9

Duration 32.92 s, Accuracy Estimate 1.752 (lower is better)

Spiral Segment 10

Duration 29.76 s, Accuracy Estimate 1.789 (lower is better)

Elel

eDurationMean 0.676073
eDurationStd 0.219007
eDurationStdnorm 0.323939
eDurationMedian 0.607519
eDurationQuartdelta 0.200006
eDurationQuartdeltanorm 0.329218
eDurationKurt 5.44106
eDurationTrenddiff -0.145004
eDurationTrendratio 0.786765
eWidthMean 8.22055
eWidthStd 3.32309
eWidthStdnorm 0.404241
eWidthMedian 7.722
eWidthQuartdelta 4.85073
eWidthQuartdeltanorm 0.62817
eWidthKurt 3.128
eWidthTrenddiff 3.861
eWidthTrendratio 1.64706
eHeightMean 17.2415
eHeightStd 4.90733
eHeightStdnorm 0.284623
eHeightMedian 16.8581
eHeightQuartdelta 7.722
eHeightQuartdeltanorm 0.45806
eHeightKurt 2.93089
eHeightTrenddiff 4.68
eHeightTrendratio 1.34188
eAspectMean 0.46902
eAspectStd 0.108553
eAspectStdnorm 0.231446
eAspectMedian 0.449919
eAspectQuartdelta 0.155212
eAspectQuartdeltanorm 0.344978
eAspectKurt 2.50608
eAspectTrenddiff 0.0928805
eAspectTrendratio 1.21954
eSlantMean 0.0558427
eSlantStd 0.169449
eSlantStdnorm 3.03441
eSlantMedian 0.0589647
eSlantQuartdelta 0.243813
eSlantQuartdeltanorm 4.1349
eSlantKurt 2.72732
eSlantTrenddiff 0.111006
eRtopMean 0.790991
eRtopStd 0.100543
eRtopStdnorm 0.12711
eRtopMedian 0.802342
eRtopQuartdelta 0.152946
eRtopQuartdeltanorm 0.190624
eRtopKurt 2.77423
eRtopTrenddiff 0.0546238
eRbotMean 0.691383
eRbotStd 0.303963
eRbotStdnorm 0.439644
eRbotMedian 0.663423
eRbotQuartdelta 0.409996
eRbotQuartdeltanorm 0.618002
eRbotKurt 3.22153
eRbotTrenddiff -0.20259
eRrightMean 0.882829
eRrightStd 0.0735353
eRrightStdnorm 0.0832951
eRrightMedian 0.889245
eRrightQuartdelta 0.112405
eRrightQuartdeltanorm 0.126405
eRrightKurt 2.93697
eRrightTrenddiff 0.0266852
eRleftMean 0.361751
eRleftStd 0.13628
eRleftStdnorm 0.376722
eRleftMedian 0.374027
eRleftQuartdelta 0.194891
eRleftQuartdeltanorm 0.521062
eRleftKurt 2.53278
eRleftTrenddiff -0.0327405
lDurationMean 0.748356
lDurationStd 0.236158
lDurationStdnorm 0.315569
lDurationMedian 0.732523
lDurationQuartdelta 0.262508
lDurationQuartdeltanorm 0.358362
lDurationKurt 4.51012
lDurationTrenddiff -0.220007
lDurationTrendratio 0.736527
lWidthMean 14.7567
lWidthStd 4.66137
lWidthStdnorm 0.315881
lWidthMedian 15.0148
lWidthQuartdelta 6.3301
lWidthQuartdeltanorm 0.421591
lWidthKurt 2.5143
lWidthTrenddiff 5.23612
lWidthTrendratio 1.44836
lHeightMean 34.2181
lHeightStd 6.04956
lHeightStdnorm 0.176794
lHeightMedian 33.9776
lHeightQuartdelta 6.33321
lHeightQuartdeltanorm 0.186394
lHeightKurt 4.79455
lHeightTrenddiff 1.0687
lHeightTrendratio 1.03208
lAspectMean 0.427803
lAspectStd 0.104379
lAspectStdnorm 0.243988
lAspectMedian 0.435392
lAspectQuartdelta 0.149632
lAspectQuartdeltanorm 0.343672
lAspectKurt 2.39838
lAspectTrenddiff 0.127395
lAspectTrendratio 1.3455
lSlantMean 0.201621
lSlantStd 0.10047
lSlantStdnorm 0.498312
lSlantMedian 0.203073
lSlantQuartdelta 0.145937
lSlantQuartdeltanorm 0.718643
lSlantKurt 2.46334
lSlantTrenddiff 0.0988345
lRtopMean 0.845135
lRtopStd 0.0608015
lRtopStdnorm 0.0719429
lRtopMedian 0.858445
lRtopQuartdelta 0.0913373
lRtopQuartdeltanorm 0.106399
lRtopKurt 2.36625
lRtopTrenddiff -0.00474896
lRbotMean 0.385824
lRbotStd 0.152937
lRbotStdnorm 0.396391
lRbotMedian 0.357563
lRbotQuartdelta 0.157913
lRbotQuartdeltanorm 0.441637
lRbotKurt 4.98084
lRbotTrenddiff -0.0422874
lRrightMean 0.912754
lRrightStd 0.0351684
lRrightStdnorm 0.03853
lRrightMedian 0.914722
lRrightQuartdelta 0.0552328
lRrightQuartdeltanorm 0.0603821
lRrightKurt 2.02873
lRrightTrenddiff -0.00593188
lRleftMean 0.258068
lRleftStd 0.0970868
lRleftStdnorm 0.376206
lRleftMedian 0.24766
lRleftQuartdelta 0.162694
lRleftQuartdeltanorm 0.656925
lRleftKurt 2.03325
lRleftTrenddiff -0.0389539

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

FITTS Short Modified

meanTouchScore 0.974515
sumTouchScores 22.4138
meanMovementTime 0.799091
numTouches 23
undershootPercentage 0
overshootPercentage 4.34783

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.830408
sumTouchScores 15.7778
meanMovementTime 1.05889
numTouches 19
undershootPercentage 5.26316
overshootPercentage 15.7895

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 22.768
timePerZigzagCoV 0.168316
timePerZigzagSlope -0.0888967
meanError 2.07183
tremorFreq 5.66406
tremorRelPower 29.7726
tremorGyroAmpMean 0.0245725
tremorGyroAmpSlope -0.000948417
tremorGyroAmpCoV 0.364629
tremorCoordAmpMean 0.131519
tremorCoordAmpSlope 0.0102346
tremorCoordAmpCoV 0.934162
tremorAccAmpMean 0.0924352
tremorAccAmpSlope -0.00109103
tremorAccAmpCoV 0.11269
tremorPcRelVar 0.837558
tremorPcX 0.0654578
tremorPcY -0.997855

ZigZag Segment 1

Duration 29.44 s, Accuracy Estimate 2.319 (lower is better)

ZigZag Segment 2

Duration 22.48 s, Accuracy Estimate 1.73 (lower is better)

ZigZag Segment 3

Duration 20.84 s, Accuracy Estimate 2.086 (lower is better)

ZigZag Segment 4

Duration 21.04 s, Accuracy Estimate 1.928 (lower is better)

ZigZag Segment 5

Duration 20.04 s, Accuracy Estimate 2.296 (lower is better)

ZigZag Offset

numZigzags 7
timePerZigzagMean 24.5143
timePerZigzagCoV 0.1975
timePerZigzagSlope -0.031352
zigzagHeightMean 81.11
zigzagHeightCoV 0.127286
zigzagHeightSlope -0.0220107
meanError 0.0877357
tremorFreq 5.17578
tremorRelPower 30.6301
tremorGyroAmpMean 0.0398746
tremorGyroAmpSlope 0.00125775
tremorGyroAmpCoV 0.533737
tremorCoordAmpMean 0.121071
tremorCoordAmpSlope -0.00593443
tremorCoordAmpCoV 2.06709
tremorAccAmpMean 0.0612869
tremorAccAmpSlope 0.000475635
tremorAccAmpCoV 0.479862
tremorPcRelVar 0.926696
tremorPcX 0.10051
tremorPcY 0.994936

ZigZag Offset Segment 1

Duration 29.96 s, Accuracy Estimate 0.107 (lower is better)

ZigZag Offset Segment 2

Duration 19.76 s, Accuracy Estimate 0.139 (lower is better)

ZigZag Offset Segment 3

Duration 22.16 s, Accuracy Estimate 0.048 (lower is better)

ZigZag Offset Segment 4

Duration 29.8 s, Accuracy Estimate 0.104 (lower is better)

ZigZag Offset Segment 5

Duration 27.56 s, Accuracy Estimate 0.109 (lower is better)

ZigZag Offset Segment 6

Duration 24.6 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 7

Duration 17.76 s, Accuracy Estimate 0.071 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.31}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.67}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.5709166340300493}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9051992069873307}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.47878504810881045}